Mechanism of radiation adaptive response of glial cells

Is Telomere Length a Biomarker of Adaptive Response? Controversial Findings of NASA and Residents of High Background Radiation Areas

Telomere length and stability is a biomarker of aging, stress, and cancer. Shortening of telomeres and high level of DNA damages are known to be associated with aging. Telomere shortening normally occurs during cell division in most cells and when telomeres reach a critically short length, DNA damage signaling and cellular senescence can be triggered. The induction of an adaptive response by sp...

Radiation-induced bystander effect and adaptive response in mammalian cells.

Two conflicting phenomena, bystander effect and adaptive response, are important in determining the biological responses at low doses of radiation and have the potential to impact the shape of the dose-response relationship. Using the Columbia University charged-particle microbeam and the highly sensitive AL cell mutagenic assay, we show here that non-irradiated cells acquire mutagenesis throug...

Radiation Bystander Effects Mechanism

  Introduction: Radiation Induced Bystander Effect (RIBE) which cause radiation effects in non-irradiated cells, has challenged the principle according to which radiation traversal through the nucleus of a cell is necessary for producing biological responses. What is the mechanism of this phenomenon? To have a better understanding of this rather ambiguous concept substantial number of original ...

Short-term exposure to high levels of natural external gamma radiation does not induce survival adaptive response

Background: In some areas of Ramsar, a city in northern Iran, residents receive a much higher annual radiation exposure than is permitted for radiation workers. Induction of adaptive response in residents of Ramsar has been reported previously. In this study induction of such a response in short term exposure to high background levels of gamma radiation is investigated. Materials and M...

The Role of Target and Bystander Cells in Dose-Response Relationship of Radiation-Induced Bystander Effects in Two Cell Lines